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Could somebody help me with AI dosing?

#1
So I’ve been on Dr. prescribed TRT for a little while now (200mg a week) and I have always used .5mg of anastrozole twice a week, the night of my injections Sunday & Wednesday. I’m currently on a blast of 500mg a week (250mg Sunday, 250g Wednesday) and I have kept my AI the same. My nipples have been a little itchy the last few days and I was thinking about upping my AI.

I’ve seen some things recommend .5mg of anastrozole EOD which I was thinking about trying, my other option was just adding .25 on Friday night so it would look like

.5mg Sunday and Wednesday then .25mg Friday. What would you guys recommend I try? Thank you I appreciate the help!
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#2
AI is something that varies quite a bit from individual to individual, so it's pretty hard to give "accurate" dosing without seeing consistent bloods from you. That said, in your position, I would indeed suggest .25-.5mg EOD for anastrozole. Since we aren't looking at your bloods, it's really just a guessing game. Too much AI can lead to low E2, which has it's own problems separate from high E2 -- we wanna try to get you to the happy medium.

I think .5mg EOD would be fine for a starting point since you are already experiencing itchy nipples. If you end up feeling that's too much, /then/ lower to .25mg. And if you're working with 1mg pressed pills, .5mg is a little easier to split them into, haha. Bite that pre-gyno in the bud before it gets anywhere.
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#3
(05-18-2019, 10:07 AM)Misriah_Rep Wrote: AI is something that varies quite a bit from individual to individual, so it's pretty hard to give "accurate" dosing without seeing consistent bloods from you. That said, in your position, I would indeed suggest .25-.5mg EOD for anastrozole. Since we aren't looking at your bloods, it's really just a guessing game. Too much AI can lead to low E2, which has it's own problems separate from high E2 -- we wanna try to get you to the happy medium.

I think .5mg EOD would be fine for a starting point since you are already experiencing itchy nipples. If you end up feeling that's too much, /then/ lower to .25mg. And if you're working with 1mg pressed pills, .5mg is a little easier to split them into, haha. Bite that pre-gyno in the bud before it gets anywhere.

Thanks for the answer! I'm currently injecting 250mg of Test E Sunday morning and 250mg Wednesday night, do you think taking .5mg of anastrozole Sunday, Wednesday, and Friday would be ok? instead of EOD? Thank you
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#4
(05-18-2019, 07:28 PM)09370z Wrote:
(05-18-2019, 10:07 AM)Misriah_Rep Wrote: AI is something that varies quite a bit from individual to individual, so it's pretty hard to give "accurate" dosing without seeing consistent bloods from you. That said, in your position, I would indeed suggest .25-.5mg EOD for anastrozole. Since we aren't looking at your bloods, it's really just a guessing game. Too much AI can lead to low E2, which has it's own problems separate from high E2 -- we wanna try to get you to the happy medium.

I think .5mg EOD would be fine for a starting point since you are already experiencing itchy nipples. If you end up feeling that's too much, /then/ lower to .25mg. And if you're working with 1mg pressed pills, .5mg is a little easier to split them into, haha. Bite that pre-gyno in the bud before it gets anywhere.

Thanks for the answer! I'm currently injecting 250mg of Test E Sunday morning and 250mg Wednesday night, do you think taking .5mg of anastrozole Sunday, Wednesday, and Friday would be ok? instead of EOD? Thank you

iirc anastrozole has a half-life of something like 30-60 hours, and some people do dose it E3D instead of EOD, so I think you would probably be okay with your Sun-Wed-Fri dosing plans.

Your AI dosing does not need to be dependent on your test E injection days other than for your personal preference/convenience. To restate, though, *ideally* you should get some kind of bloodwork to make sure this extra .5mg isn't making your estrogen *too low* if you dose it this way long term. How everyone responds to their AI and how they aromatize at certain test doses is different from individual to individual.

Best of luck with your cycle/blast, I hope you're enjoying the benefits so far~! Smile
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#5
(05-18-2019, 07:28 PM)09370z Wrote:
(05-18-2019, 10:07 AM)Misriah_Rep Wrote: AI is something that varies quite a bit from individual to individual, so it's pretty hard to give "accurate" dosing without seeing consistent bloods from you. That said, in your position, I would indeed suggest .25-.5mg EOD for anastrozole. Since we aren't looking at your bloods, it's really just a guessing game. Too much AI can lead to low E2, which has it's own problems separate from high E2 -- we wanna try to get you to the happy medium.

I think .5mg EOD would be fine for a starting point since you are already experiencing itchy nipples. If you end up feeling that's too much, /then/ lower to .25mg. And if you're working with 1mg pressed pills, .5mg is a little easier to split them into, haha. Bite that pre-gyno in the bud before it gets anywhere.

Thanks for the answer! I'm currently injecting 250mg of Test E Sunday morning and 250mg Wednesday night, do you think taking .5mg of anastrozole Sunday, Wednesday, and Friday would be ok? instead of EOD? Thank you

I mean, you *could* do it Mon-Wed-Fri instead of EOD, but it isn't as optimal. EOD will result in a lot less spikes in E2; whether it would be a huge difference, I doubt it. The biggest difference is just the dosing; there are 3.5 doses a week if you dose EOD, and 3 doses a week if you dose on Mon-Wed-Fri.

EOD is harder for people to keep track of though, since everyone's schedule is set up weekly, so a lot of people do what you are planning to do.

But I would suggest you get bloodwork to actually see what your E2 is at. They are relatively cheap, only like $50-100 if all you care about is E2.
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#6
fwiw, i find taking my AI the day after pinning works best. Gives time for the peaks to hit, then the AI to be in more lock step with the highs. I am pinning 200mg 3 times a week, M, W, F, and AI @ .5 Tues, Thurs, and Sat.
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